Question? Do we include toxic trees? If so, I would like to nominate the Ohio Buckeye (also known as the Stinking Buckeye).
Let's see...the bark and fruit (called buckeyes b/c they resemble the eye of a deer) contain the glucoside aesculin which is poisonous to cattle, pigs, horses and people. The tree usually is smallish w/ extroadinarily weak wood. Farmers often fell them so their livestock won't eat the fruit which even squirrels won't touch.
Why Ohio would pick it as a state symbol is beyond me. The term fetid or stinking comes from the fact that crushing the bark yields a nasty odor.
Of course, my opinion might be biased being a native Kentuckian and all
Randy